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Cancer is the name given to a large group of
diseases, all of which have one thing in common: cells that
are growing out of control. Normally, the cells that make
up all of the parts of our bodies go through a predictable
life cycle -- old cells die, and new cells arise to take their
place. Occasionally, this process goes awry, and cells begin
to multiply out of control. The end result is a mass of cells,
called a tumor. A benign tumor is one that does not spread,
or metastasize to other parts of the body. It is considered
noncancerous. A malignant tumor, on the other hand, can spread
throughout the body and is considered cancerous. When malignant
cells break away from the primary tumor and settle into another
part of the body, the resulting new tumor is called either
a metastasis or a secondary tumor.
There are several major types of cancers: carcinomas
form in the cells that cover the skin or line the mouth, throat,
lungs and organs; sarcomas are found in the bones, muscles,
fibrous tissues and some organs; leukemia are found in the
blood, the bone marrow, and the spleen; and lymphomas are
found in the lymphatic system.
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Cancer often takes many years to develop. The
process typically begins with some disruption to the DNA of
a cell, the genetic code that directs the life of the cell.
There can be many reasons for disruptions, such as diet, tobacco,
sun exposure, reproductive history or certain chemicals. Some
cells will enter a precancerous phase, known as dysplasia.
Some cells will progress further to the state of carcinoma
in situ, in which the cancer cells are restricted to a microscopic
site, surrounded by a thick covering and do not pose a great
threat.
Eventually, unless the body's own immune system
takes care of the wayward cells, a cancer will develop. It
may take as long as 30 years for a tumor to go through the
entire process and become large enough to produce symptoms.
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Since cancer can arise from such a wide variety
of sites and develop with many differing patterns of spread,
there are no clear-cut symptoms . Cancer is unlike many more
specific diseases such as heart disease or arthritic disease.
The precise nature of symptoms of cancer depends not only
on primary site but specifically where the tumor is located
in an organ, rate of development and also secondary spread
is present or not.
Many primary tumors cause local swelling or lump
if they arise at a visible or accessible part of the body,
such as a skin, breast, testicle or oral cavity. A typical
swelling due to a cancer is initially painless, though ulceration
(skin breakdown) can occur, which may then become painful.
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The aim of cancer treatment is to cure the patient
and save life. The cases where complete cure is not possible,
treatment aims to control the disease and to keep the patient
normal and comfortable as long as possible. The treatment
of each patient is designed to suit an individual and depends
on the age of the patient, stage and type of disease. There
may be only one treatment or combination of treatments. There
are four main modalities of treatment : Surgery, Radiation
therapy, Chemotherapy, hormonetherapy and Immunotherapy. Surgery
and radiotherapy aim at eradicating the disease at the primary
site (site of origin) of cancer whereas chemotherapy, hormonetherapy
and immunotherapy deal with disease which may have spread
outside the site of origin of cancer. Surgery is the most
important part of the cancer treatment. Surgery attempts to
remove cancer cells from the body by cutting away the tumor
and any tissues surrounding it which may contain cancer cells.
It is a simple, safe and effective method when cancer is small
and confined to the site of origin. It is best suited for
certain type of cancers such as, breast cancer, head and neck
cancers, early cancers of the cervix and lung, many skin cancers,
soft tissue cancers and gastrointestinal cancers. Radiotherapy
has become the pre-eminent form of cancer treatment since
beginning of this century and now it is used for fifty percent
of patients. Improvements in radiotherapy equipment, technique
and applications, have led to an increasing role both in local
treatment and also in its use as a whole-body treatment ,
as part of bone marrow transplantation techniques for leukaemia
and other malignant diseases.
Radiation is a special kind of energy carried
by waves or a stream of particles originating from radioactive
substances and delivered by special machines. These radioactive
x-rays or gamma rays can penetrate the cell wall and damage
the nucleus of the cell which prevents growth and division
of cells. This also affects the normal cells but these cells
recover more fully than cancer cells. Chemotherapy uses drugs
which interfere with the growth and division of malignant
cells. Once the drugs are administered, they circulate throughout
the body. It is advantageous over surgery & radiation for
treating cancer that is systemic (spread throughout the body).
Chemotherapy is very useful in treating cancers like leukemia,
lymphomas, testicular cancer. Chemotherapy can be given as
the primary treatment, or following surgery or radiotherapy
to prevent reappearance of cancer.
The side-effects of the chemotherapy include
nausea, vomiting, hair loss, fever etc. which are temporary
and completely reversible. Hormone therapy has limited use
in cancer treatment since only a small minority of tumors
are hormone sensitive e.g. breast and prostate cancer. This
therapy provides systemic means of treatment, i.e. to the
whole body, but without the side effects of chemotherapy.
In summary, it is misconception that all cancers are incurable.
Current methods of treatment are effective for many cancers.
A large number of cancer patients are cured and more patients
could be cured if their cancers were detected early and treated
promptly.
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