- JAMA 1999 May 5 ; 281 (17) : 1586
Intensive vs clinical follow up after treatment of primary breast cancer : 10 – years update of randomized trial. National Research council project on breast cancer follow-up.
Palli D, Russo A, Saieva C, Ciatto S, Rosselli Del,Turco M, Distante V, Pacini P.
INTERVENTION : Patients in both treatment groups had physical examination and mammography, while patients of the intensive follow-up group had , in addition , chest x-ray and bone scan every 6 months.
CONCLUSIONS : Periodic chest X-ray and bone scan allow earlier detection of distant metastases, but anticipated diagnosis appears to be the only effect of intensive follow-up, and no impact on prognosis is evident after 10 years. Periodic intensive follow-up with chest X-ray and bone scan should not be recommended as a routine policy.
- JAMA. 1994 May 25; 271 (20) : 1587-92
Impact of follow-up testing on survival and health-related quality of life in breast cancer patients. A multicenter randomized controlled trial. The GIVIO investigations.
INTERVENTION :Patients were randomly assigned to an intensive surveillance, which included physician visits and performance of bone scan, liver USC, chest X ray, and laboratory tests at regular intervals or to a control regimen, in which patients were seen by their physicians at the same frequency but only clinically indicated tests were performed. Both groups received a yearly mammogram aimed at detecting contralateral breast cancer.
CONCLUSION :Results of this trial support the view that a protocol of frequent laboratory tests and X rays / USG after primary treatment for breast – related quality of life. Routine use of these tests should be discouraged.